ABSTRACT
Tetrapleura tetraptera stem bark has been reported to cause inhibition of luteinizing hormone release in cultured rat pituitary cells. Hence, we investigated the effects of Tetraptera tetrapleura pod extract on follicle stimulating hormone, luteinizing hormone, cortisol, progesterone and estrogen. Thirty non-pregnant female wistar albino rats were divided into group A - D. Group A rats were used as Control. Group B rats were administered 1 mg/kg/day of clomiphene citrate orally. Group C rats were administered 200 mg/kg of extract only, whereas group D rats were administered 1 mg/kg /day of Clomiphene citrate plus 200 mg/kg of extract. At the end of 14 days experiment, group A, B and D were found in proestrus phase and group C in diestrus phase. FSH and cortisol levels remained unchanged. Group C and D rats produced significant reduction (P < 0.05) in LH and estrogen levels in prolonged proestrus and normal diestrus respectively. Progesterone level was significantly high (P < 0.05) in the group C rats. The reduced LH level could be due to the anti-estrogenic effect of extract during proestrus when LH secretion is expected to surge. But co-administration resulted in high progesterone secretion, suggesting extract may have influenced progesterone secretion in group D rats simultaneously administered with clomiphene citrate and extract. The above findings indicated that Tetrapleura tetraptera pod extracts inhibited luteinizing hormone and estrogen even when co-administered with clomiphene citrate.
ABSTRACT
Background: Osteoarthritis is a major cause of disability and incapacitation Worldwide. Aim: To evaluate the epidemiology and pattern of osteoarthritis at Ogbaku, Imo State University Teaching Hospital annex, Mbaitoli Local Government Area, Imo State, South-east Nigeria. Study Design: A retrospective epidemiological study. Methodology: One hundred and six case notes of patients managed for osteoarthritis between January 2009 and October 2010 were studied. Simple statistical methods like percentages were used for data analysis. Results: Out of 106 cases studied, 72(67.9%) were females while 43(32.1%) were males. The highest percentage of cases (34%) occurred in people aged 65-74 years followed by people aged 55-64 years (24.5%). Younger people (45-54 years) were the least affected. Farmers (24.5%) were the most affected occupational group followed by athletes (18.9%) and then traders (17%). Civil servants were the least affected. The knee (41.5%) was the most frequently affected joint followed by the hip (22.6%). The least affected joints were the wrist (1.9%) and the elbow (1.9%). Conclusion: The study shows that osteoarthritis occurred most in people aged 65-74 yrs and the knee was the most frequently affected joint in the body.
ABSTRACT
The effect of marital status and self-reported exercise was investigated in a sample of Igbos in Nigeria. Physical activity level was grouped into: no exercise; irregular exercise and regular exercise. In all the groups; adiposity level and mean BP decreases as the frequencies of physical activity increases and these were significant for weight; BMI; diastolic BP; body circumferences; skinfold thickness except CSF among the married men; while for the never married men significant difference exist only for WC; FAC; SSF among the three groups. For the married women; the three groups of physical activity recorded significant difference in Weight; BMI; WC and HC while the never married women had significant difference only in CSF (F = 4.5; P = 0.01). The result of this study suggests that sex; marital status and exercise have effect on adiposity and blood pressure of the subjects. The married state was conducive for the development of excess adiposity and elevated BP while regular participation in exercise brings a reduction in fat stores and blood pressure. In conclusion; there is a greater tendency for married individuals to be overweight as compared to the never married subjects and regular physical exercise has strong influence in reducing the propensity to increase weight in both men and womenhttp://www.akspublication.com/Paper02_Jan2009_.pdf